Dr. Constantine (Dean) Karvellas is a Professor of Medicine (Critical Care Medicine and Gastroenterology/Hepatology) at the University of Alberta and an Adjunct Professor in the School of Public Health Sciences. He has been an attending intensivist in the E. Garner King General Systems Intensive Care Unit since 2009 and is involved with the Liver Transplant program as a Hepatologist. Dr. Karvellas is the only Canadian co-investigator in the NIH-funded United States Acute Liver Failure study group (US ALFSG). He is an Associate Editor for the Journal of Hepatology and a Vice-chair of the Society of Critical Care Medicine (SCCM) Liver management task force. Dr. Karvellas has over 100 publications reflecting his interests in acute liver failure (ALF), acute on chronic liver failure (ACLF), liver transplantation and extracorporeal liver support.

Position/Title: Professor of Medicine

Institution: Faculty of Medicine and Dentistry, University of Alberta

Department: Critical Care Medicine and Medicine (Gastroenterology/Liver Unit)

Email: Dean.karvellas@ualberta.ca

Institutional Profile: https://www.ualberta.ca/critical-care/about-us/department-members/index.html?details=constantine-j-karvellas-md-msc-frcpc-fccm

Areas of Expertise: Acute liver failure: Clinical and translational; Acute or chronic liver failure (cirrhosis and critical illness); Clinical outcomes in liver transplantation; Artificial liver support/extracorporeal blood purification

Names of Current Grants/Project Titles: 

2013-2021. National Institutes of Health: NIDDK U01-DK-583. United States Acute Liver Failure Study Group; $5,000,000.00 USD (overall study) ($500,000.00 CAD for Karvellas/University of Alberta 2013-2021).

Select Publications: 

Karvellas CJ, Speiser JL, Tremblay M, Lee WM, Rose CF. Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure. Hepatology.2017 Mar;65(3):938-949. 

Cardoso FS, Gottfried M, Tujios S, Olson JC, Karvellas CJ; US Acute Liver Failure Study Group. Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure. 2018 Feb 67(2):711-720.

Karvellas CJ, Garcia-Lopez E, Fernandez J, Saliba F, Sy E, Jalan R, Pavesi M, Gustot T, Ronco JJ, Arroyo V; Chronic Liver Failure Consortium and European Foundation for the Study of Chronic Liver Failure. Dynamic Prognostication in Critically Ill Cirrhotic Patients with Multiorgan Failure in ICUs in Europe and North America: A Multicenter Analysis. Crit Care Med. 2018 Nov;46(11):1783-1791.

Nanchal R, Subramanian R, Karvellas CJ, et al..: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations. Crit Care Med2020; 48: e173-e191.

 MacDonald AJ, Speiser JL, Ganger DR, Nilles KM, Orandi BJ, Larson AM, Lee WM, Karvellas CJ ; United States Acute Liver Failure Study Group. Clinical and neurological outcomes in acetaminophen-induced acute liver failure: a twenty-one-year multicenter cohort study. Clin Gastroenterol Hepatol. 2020 Sep 10: S1542-3565(20)31273-8.