Sean van Diepen

Sean van Diepen is an academic Cardiologist-Intensivist with a medical staff appointment at the University of Alberta Hospital. He is co-director of the Coronary Intensive Care Unit at the University of Alberta Hospital. Dr. van Diepen is an Associate Professor of Critical Care Medicine in the Department of Critical Care, and is cross appointed to the Division of Cardiology (Department of Medicine) at the University of Alberta. He is also a faculty member of the Canadian VIGOUR Centre (Virtual Coordinating Centre for Global Collaborative Cardiovascular Research). Dr. van Diepen completed medical school at the University of Toronto, and after moving west, he undertook Internal Medicine, Cardiology and Critical Care Training at the University of Alberta. He completed a Clinical Research Fellowship at the Duke Clinical Research Institute in Durham, North Carolina and received his Masters of Science in Experimental Medicine from the University of Alberta.

Position/Title: Associate Professor of Critical Care Medicine / Faculty Member, The Canadian Vigour Center / Coronary Intensive Care Unit Co-Director

Institution: University of Alberta

Department: Department of Critical Care Medicine / Division of Cardiology, Department of Medicine 

Areas of Expertise: Critical Care Cardiology; Cardiogenic Shock; Cardiac Arrest; Cardiovascular Surgical Intensive Care

Select Publications: 

van Diepen S, Hochman J, Stebbins A, Alvair C, Alexander J, Lopes R. Association between delays in mechanical ventilation initiation and mortality in patients with refractory cardiogenic shock. JAMA Cardiology 2020. doi:10.1001/jamacardio.2020.1274

Katz JN, Sinha SS, Alviar CL, Dudzinski DM, Gage A, Brusca SB, Flanagan MC, Welch T, Geller BJ, Miller PE, Leonardi S, Bohula EA, Price S, Chaudhry SP, Metkus TS, O’Brien CG, Sionis A, Barnett CF, Jentzer JC, Solomon MA, Morrow DA, van Diepen S. Disruptive Modifications to Cardiac Critical Care Delivery During the Covid-19 Pandemic: An International Perspective. Journal of the American College of Cardiology 2020; DOI: 10.1016/j.jacc.2020.04.029.

van Diepen S, Tymchak W, Bohula EA, Park JG, Daniels LB, Phreaner N, Barnett CF, Kenigsberg BB, DeFilippis A, Singam NS, Barsness GW, Jentzer JC, Ternus B, Morrow DA, Katz JN, on behalf of the Critical Care Cardiology Trials Network Investigators. Incidence, Underlying Conditions, and Outcomes of Patients Receiving Acute Renal Replacement Therapies in Tertiary Cardiac Intensive Care Units: An analysis from the Critical Care Cardiology Trials Network Registry. American Heart Journal 2020; DOI: 10.1016/j.ahj.2020.01.005 

Woolridge S, Alemayehu W, Kaul P, Fordyce CB, Lawler PR, Lemay M, Jentzer JC, Goldfarb M, Wong GC, Armstrong PW, van Diepen S. National Trends in Coronary Intensive Care Unit Admissions, Resource Utilization and Outcomes.  European Heart Journal Acute Cardiovascular Care 2019; DOI: 10.1177/2048872619883400

van Diepen S, Katz JN, Morrow DA. Will cardiac intensive care unit admissions Warrant Appropriate Use Criteria in the Future? Circulation 2019, 2019;140:267–269.  DOI: 10.1161/CIRCULATIONAHA.118.039125

Mehta RH, Leimberger JD, van Diepen S, Meza J, Wang A, Jankowich R, Harrison RW, Hay D, Fremes S, Duncan A, Soltesz EG, Luber J, Park S, Argenziano M, Murphy E, Marcel R, Kalavrouziotis D, Nagpal D, Bozinovski J, Toller W, Heringlake M, Goodman SG, Levy JH, Harrington RA, Anstrom KJ, Alexander JH. Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery New England Journal of Medicine 2017; 375: 2032-2042

van Diepen S, Fuster V, Verma S, Hamza TH, Siami FS, Goodman SG, Farkouh ME. Dual anti-platelet therapy versus aspirin alone after CABG in diabetics with multi-vessel disease: FREEDOM Insights. Journal of the American College of Cardiology 2017; 69 (2): 119-127

van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, Kilic A, Menon V, Ohman EM, Sweitzer NK, Thiele H, Washam JB, Cohen MG, on behalf of the American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association. Circulation. 2017;136; e232-268: doi: 10.1161/CIR.0000000000000525 

van Diepen S, Lin M, Bakal JA, McAlister FA, Kaul P, Katz JN, Fordyce C, Southern DA, Graham MM, Wilton SB, Newby LK, Granger CB, Ezekowitz JA. Do Patients with Uncomplicated Non-ST Segment Acute Coronary Syndromes Require Admission to Critical Care Units? American Heart Journal 2016; 175: 184–192

van Diepen S, Reynolds HR, Stebbins A, Lopes RD, D┼żavík V, Ruzyllo W, Geppert A, Widimsky P, Ohman EM, Parrillo JE, Dauerman HL, Baran DA, Hochman JS, Alexander JH. Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock. Critical Care Medicine 2014; 42(2):281-288.