DR. STEPHANE L BOURQUE

Dr. Bourque is currently Assistant Professor in the Department of Anesthesiology and Pain Medicine at the University of Alberta. He received his PhD from Queen’s University in the Department of Pharmacology and Toxicology, then pursued a postdoctoral fellowship at the University of Alberta. His research program focuses on two areas: (i) the mechanisms underlying the development of vasoplegia and its progression to septic shock, and (ii) the mechanism by which fetal stressors (such as iron deficiency) impact fetal growth and development of the cardiovascular system. His research program is currently funded by the Canadian Institutes of Health Research, the CCSCN, the Women and Children’s Health Research Institute at the University of Alberta, and the Canadian Foundation for Innovation. 

Position/Title: Assistant Professor

Institution: University of Alberta

Department: Anesthesiology & Pain Medicine

Email: Sbourque@ualberta.ca

Accepting Trainees: Yes

Current Lab Members: Ms. Sareh Panahi (lab manager); Dr. Farough Jahandideh (postdoctoral fellow) Dr. Kimberly Macala (PhD student); Andrew Woodman (PhD student).

Links to Personal Web Sites:

Link to Institutional Profile: https://www.ualberta.ca/medicine/about/people/stephane-bourque

Copy of Current CV: Download

Areas of Expertise: Vascular function; Sepsis; Developmental origins of health and disease; Iron deficiency.

Names of Current Grants/Project Titles:

CCSCN New Investigator Grant: "Pre-clinical testing of novel treatment strategies for septic shock in a mouse model of advanced age.”

Developmental programming of cardiovascular function by iron deficiency: early mechanisms and therapeutic interventions.”

Mechanisms underlying propofol-induced hypotension in normal and accelerated aging.”

Select Publications: 

Woodman AG, Care AS, Mansour Y, Cherak S, Panahi S, Gragasin FS, BOURQUE SL. Modest and severe maternal iron deficiency in pregnancy are associated with fetal anaemia and hypoxia in rats. Sci Reports.

Care AS, Sung M, Panahi S, Gragasin FS, Dyck JRB, Davidge ST, BOURQUE SL. Prenatal and immediate postnatal maternal resveratrol treatment mitigates the development of hypertension in adult SHR offspring. Hypertension. 2016 May;67(5):1038-44.

BOURQUE SL, Gragasin F, Mansour Y, Quon A, Morton J, Davidge ST. Prenatal hypoxia causes long-term alterations in vascular endothelin-1 function in aged male but not female offspring. Hypertension. 2013 Oct;62(4):753-8.

Gragasin FG, BOURQUE SL, Davidge ST. Propofol increases vascular relaxation in aged rats chronically treated with the angiotensin converting enzyme inhibitor captopril. Anesth Analg. 2013 Apr;116(4):775-83.

Gragasin FG*, BOURQUE SL*, Davidge ST. Vascular aging and hemodynamic stability in the perioperative period. Front Physiol. 2012; 3:74. (Review)

BOURQUE SL*, Whittingham HA*, Brien SE, Davidge ST, Adams MA. Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition. Br J Pharmacol. 2012 Mar; 165(6):1992-9. (2012 IF: 5.067)