2017 - 2018. PRE CLINICAL TESTING OF NOVEL TREATMENT STRATEGIES FOR SEPTIC SHOCK IN A MOUSE MODEL OF ADVANCED AGE

Project Title: Preclinical testing of novel treatment strategies for septic shock in a mouse model of advanced age.

Overview: Sepsis (blood poisoning) is overwhelming infection in the body. It is a common cause of Intensive Care Unit admission and death in Canada. Patients over the age of 60 make up over 60% of all sepsis hospitalizations in Canada. The older the sepsis patient, the greater the risk of dying. Yet despite the preponderance of elderly people affected by sepsis, most current available evidence is obtained using young animal models. To better understand how sepsis progresses in the elderly patient, we propose to study the cardiovascular effects in sepsis using aged animals, because aged rodents exhibit similar changes in blood pressure regulation as the elderly. Our study will examine the cardiovascular changes in aged septic rodents and we will study the causes of sepsis that lead to accelerated death in the elderly. We will also test new combinations of medications already approved for other cardiovascular complications to improve survival and blood pressure recovery after the onset of sepsis.

Primary Investigator: Stephane Bourque

Research Associates: Dr. Rachel G. Khadaroo; Dr. Kimberly Macala; Dr. Ferrante Gragasin

Patient and Family Advisors: None

Award: CC SCN New Investigator Seed Funding Grant

Funding Body: Critical Care Strategic Clinical Network