COMPARATIVE SAFETY AND EFFICACY OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR THE BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS

Project Title: Comparative Safety and Efficacy of Pharmacological and Non-Pharmacological Interventions for the Behavioral and Psychological Symptoms of Dementia: A Systematic Review and Network Meta-Analysis

Primary Investigator: Zahra Goodarzi

Research Associates: Jennifer Watt; Andrea Tricco; Areti-Angeliki Veroniki; Sharon Straus

Patient and Family Advisors: N/A

Award: Late Life Seed Funding, co sponsored by the CCSCN

Funding Body: CCSCN

Overview:

Dementia is a brain disease that often leads to changes in memory and the ability to do activities of daily living independently. Patients with dementia can also have symptoms such as depression, anxiety, and changes in behavior (e.g. aggression, agitation) throughout the course of their disease.

Medications (e.g. antidepressants, antipsychotics) and other therapies (e.g. aromatherapy, reminiscence therapy) can be helpful treatments for these symptoms; however, it’s not clear what treatment is the most efficacious or safe. This is important because some of these medications have been associated with serious side effects including pneumonia, stroke, and heart attack, which can potentially lead to hospitalization, admission to the intensive care unit, or death. This proposed study will rank treatments as to their risks and benefits to help patients, clinicians, and caregivers pick the

best treatment option based on patients’ values and preferences.

Citations: 

Watt J, Goodarzi Z, Tricco AC, Veroniki AA, and Straus SE. Comparative safety and efficacy of pharmacological and non-pharmacological interventions for the behavioral and psychological symptoms of dementia: protocol for a systematic review and network meta-analysis. Systematic Reviews (2017) 6:182.